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KMID : 0923620220220030027
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Immune Network
2022 Volume.22 No. 3 p.27 ~ p.27
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Characterization of Immune Cells From the Lungs of Patients With Chronic Non-Tuberculous Mycobacteria or Pseudomonas aeruginosa Infection
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Schenkel Alan R.
Mitchell John D.
Cool Carlyne D.
Bai Xiyuan
Groshong Steve
Koelsch Tilman
Verma Deepshikha
Ordway Diane J.
Chan Edward D.
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Abstract
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Little is known of the lung cellular immunophenotypes in patients with non-tuberculous mycobacterial lung disease (NTM-LD). Flow-cytometric analyses for the major myeloid and lymphoid cell subsets were performed in less- and more-diseased areas of surgically resected lungs from six patients with NTM-LD and two with Pseudomonas aeruginosa lung disease (PsA-LD). Lymphocytes, comprised mainly of NK cells, CD4+ and CD8+ T cells, and B cells, accounted for ~60% of all leukocytes, with greater prevalence of T and B cells in more-diseased areas. In contrast, fewer neutrophils were found with decreased number in more-diseased areas. Compared to NTM-LD, lung tissues from patients with PsA-LD demonstrated relatively lower numbers of T and B lymphocytes but similar numbers of NK cells. While this study demonstrated a large influx of lymphocytes into the lungs of patients with chronic NTM-LD, further analyses of their phenotypes are necessary to determine the significance of these findings.
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KEYWORD
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Leukocytes, Lung, Non-tuberculous mycobacteria, Pseudomonas aeruginosa, Lymphocytes
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